As the live-action Spider-Man movie was released in 2002, a game developed by Treyarch titled, Spider-Man: The Movie was developed for PC, PlayStation 2, Xbox and Nintendo GameCube with a separate title developed by Digital Eclipse Software for Game Boy Advance. The game play was similar to that of Neversoft's previous Spider-Man game, except it featured for the first time aerial combat, and to an extent allowed the user to 'web sling' over New York openly, although not being able to land on the ground below. The game sported the voice of the actors from the film, including Tobey Maguire, Willem Dafoe, cult icon Bruce Campbell, and including Josh Keaton as Harry Osborn and in a bonus story-mode where he wears Harry's Green Goblin gear.

After the critical success of both the first Spider-Man film and the video game releases, Marvel ordered a wider selection of titles to coincide with the release of Spider-Man 2. The flagship titles being Treyarch's Spider-Man 2: The Game for PlayStation 2, Xbox and Nintendo GameCube, which extended the open environment concept started by their previous title. Unlike the previous generation of games based on the film, Treyarch's game was not released for the PC, and in its stead was an original game developed by Fizz Factor. The reasons for this remain unclear, and Fizz Factors game did not include the open environment game play as seen in Treyarch's game and appeared to be targeted towards a younger audience, despite the game being marketed the same as the console release. Later, in 2005, another version ofSpider-Man 2, this time for Sony's new handheld, the PlayStation Portable; which debuted in the first quarter of the year along with the system, was released. The PSP version of Spider-Man 2 was the first action games for the PSP, Spider-Man has to stay at a certain height, and Vulture is exclusive to the PSP version.

A game was also released alongside the Fizz Factor PC game titled, Spider-Man 2 Activity Center, featuring puzzles and mini games clearly targeted at young children.